HORDB

ID: hor001644
Uniprot ID: Q8JIM3
Protein name: fGRP-related peptide 1
Gene name: NA
Organism: Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Observed in the suprachiasmatic nucleus and in several telencephalic and diencephalic regions.
Disease: NA
Comments: NA
Taxonomy: Lithobates (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003674 molecular_function
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0046879 hormone secretion
GO CC: GO:0005576 extracellular region

Sequence: SIPNLPQRF
Length: 9(128-136)
Propeptide: MHLKIGTLTIRTIMLFTLCTFLTLFAFSTCFDETKTINLESQEIYDDLFESKEDLQNERNGNSDEYRYMGSNSINDINRYNRLSMQPENEFLQERSLKPAANLPLRFGRTSDDKIAKSIPSFDKIAKSIPNLPQRFGRYLSGKTKVQSMANLPQRFGRAQYTNHFVHSLDTLPLRFGRTPHSDRLQYEMNSHPLELKNPEEDSDRKKRQAMTFRIRTDLQM
Signal peptide: MHLKIGTLTIRTIMLFTLCTFLTLF
Modification: T9 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Primary role is to release GH from the pituitary. May act as an endogenous ligand in the bullfrog hypothalamo-hypophysial system.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001644_AF2.pdb

hor001644_ESM.pdb

Mass:	121411	Formula:	C49H78N14O13
Absent amino acids:	ACDEGHKMTVWY	Common amino acids:	P
pI:	10.55	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	3
Hydrophobicity:	-48.89	Boman Index:	-1768
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	86.67
Instability Index:	4848.89	Extinction Coefficient cystines:	0
Absorbance 280nm:	0